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In GROMACS, "constraints" and "restraints" refer to different simulation processes. Constraints are used to fix the length of (a subset of) bonds after the integration of forces. Restraints come in a number of flavours, and involve perturbing the Hamiltonian so that the ensemble it produces fits some preconceived notion, such as implementing an energy penalty for deviating from a defined value (in the case of atomic positions, dihedral angle, etc). See the GROMACS Manual for more information.
